{"id":8960,"date":"2026-03-04T14:19:52","date_gmt":"2026-03-04T13:19:52","guid":{"rendered":"https:\/\/www.peptidlab.com\/?page_id=8960"},"modified":"2026-03-04T15:18:24","modified_gmt":"2026-03-04T14:18:24","slug":"mots-c-mechanizmus","status":"publish","type":"page","link":"https:\/\/www.peptidlab.com\/en\/mots-c-mechanizmus","title":{"rendered":"MOTS-c mechanism"},"content":{"rendered":"
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
<\/div>\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t

Peptid lab<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t

MOTS-c \u2013 mechanism of action and research context<\/h1>\t\t\t\t<\/div>\n\t\t\n\t\t
\n\t\t\t\t\t\t\t\t\t

MOTS-c is a mitochondria-derived peptide of interest in cellular energy and metabolic research. Unlike conventional peptides encoded by nuclear DNA, MOTS-c originates from mitochondrial DNA, making it a unique subject of study.<\/p>

In research settings, its role in regulating cellular metabolism, adaptive responses to energy stress and signalling pathways associated with metabolic balance is of particular interest.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tShop<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t
\n\t\t\t\t\t
\n\t\t
\n\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\n\t\t\t\t\t
What is MOTS-c? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
\n\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a short bioactive peptide encoded by the mitochondrial genome.<\/p>

Mitochondria are known as the cell\u2019s \u201cenergy centres\u201d. In addition to producing energy, however, they also play an important role in cell signalling.<\/p>

MOTS-c is part of this signalling communication between the mitochondrion and the cell nucleus.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

\n\t\t\t\t\n\t\t\t\t\t
How MOTS-c works \u2013 the mechanism step by step <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

The mechanism of action of MOTS-c is under investigation, but can be described in simple terms as follows:<\/p>

  1. Detection of metabolic stress<\/strong>
    Changes in energy conditions within the cell activate adaptive mechanisms.<\/p><\/li>

  2. Signalling activation<\/strong>
    MOTS-c is involved in regulating metabolic pathways related to energy use.<\/p><\/li>

  3. Interaction with the cell nucleus<\/strong>
    Research suggests that it may influence the expression of genes involved in metabolic regulation.<\/p><\/li>

  4. The cell\u2019s adaptive response<\/strong>
    Metabolic processes are adjusted in response to energy demands.<\/p><\/li><\/ol>

    This process is the subject of intensive laboratory investigation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

    \n\t\t\t\t\n\t\t\t\t\t
    MOTS-c and cellular energy <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

    One of the main research areas is the relationship between MOTS-c and mitochondrial function.<\/p>

    Relationships are being studied with:<\/p>